【摘要】 目的观察纳洛酮联合亚低温治疗急性脑梗塞的临床效果。方法将70例急性脑梗塞患者随机分为两组,每组35例。两组均给予纳洛酮治疗,在此基础上,治疗组加用亚低温(肛温)33±0.5℃处理(24~48h),分别于治疗后第2、4周对患者进行格拉斯哥昏迷评分(GCS)、神经功能缺损评分(NDS)及临床疗效评定。结果治疗组NDS和GCS评分均显著优于对照组(P<0.01或0.05),治疗组的显效率和总有效率也明显高于对照组(P<0.05或0.01)。结论纳洛酮联合亚低温治疗急性脑梗塞比单用纳洛酮更有效。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Naloxone combined with moderate hypothermia in treatment of acute brain infarction. Methods Seventy patients with acute brain infarction were randomly allocated to two groups, thirty-five cases in each group. The two groups were given Naloxone treatment, based in this treatment, the therapeutic group received mild hypothermia at (rectal temperature) 33±0.5℃ (management for 24～48 hours). Two and four weeks after treatment, GCS and NDS were used for clinical efficacy evaluation, respectively. Results In the therapeutic group, the scores of NDS and GCS evaluation were higher than those in the control group, there were statistically significant differences (P<0.01 or 0.05, respectively); the excellent rate and total efficiency rate were also higher than those in the control group, there were statistically significant differences (P<0.05 or 0.01, respectively). Conclusion Naloxone combined with mild hypothermia in treatment of acute brain infarction is more effective than single naloxone.更多还原