【摘要】 为了寻找高活性的Hill反应抑制剂,以β-氨基丙酸为原料,经过四步反应,合成了一系列未经文献报道的3-取代硫代氢化脲嘧啶.所有新化合物的结构均经过1HNMR,IR和元素分析证.初步的生物活性测试表明,所合成的化合物能有效地抑制Hill反应,如化合物5j有很高的抑制活性(IC50=0.82μg?mL-1).更多还原

【Abstract】 In order to find highly active inhibitors of Hill reaction, a series of thiohydrouracil derivatives have been synthesized by a four-step synthetic route. The structures of all compounds were confirmed by elemental analysis, 1H NMR and IR spectra. Preliminary bioassay showed that these compounds could inhibit Hill reaction effectively, for example, compound 5j exhibited high inhibitory activity with IC50=0.82 μg?mL-1.更多还原