【摘要】 通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a～3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应,合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1’,2’,4’-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a～4m.化合物结构经元素分析,1HNMR,IR和MS进行了表征.抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性.更多还原

【Abstract】 The synthesis of novel 4-substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-s-triazolo[3,4- b]-1’,3’,4’-thiadiazines (4a～4m) by the condensation of 4-amino-5-mercapto-3-substituted-1,2,4-triazoles (3a～3m) with 2-bromo-2-(1H-1,2,4-triazol-1-yl)-4′-chloroacetophenone (2) was described. The structures of compounds were confirmed by elemental analyses, IR, 1H NMR and mass spectral data. These com- pounds have also been screened for their antibacterial activities.更多还原