【摘要】 目的探讨腰麻-硬膜外联合麻醉用于分娩镇痛对产妇血清催乳素(PRL)的影响。方法选择200例产妇随机分为观察组(Ⅰ组)和对照组(Ⅱ组),每组100例。Ⅰ组在宫口开至2~3cm时开始行腰麻-硬膜外联合麻醉,腰麻药为0.1%布比卡因+20μg芬太尼共2 ml;Ⅱ组按产科常规处理。分别在宫口开全时、产后2 h及24 h抽取产妇静脉血用放免法测定血清PRL,并观察镇痛效果及哺乳情况。结果腰麻-硬膜外联合麻醉镇痛效果良好,Ⅰ组在宫口开全时血清PRL显著高于Ⅱ组(P<0.01),而两组产妇在产后2 h及24 h血清PRL及泌乳始动时间差异无显著性。结论腰麻-硬膜外联合麻醉用于分娩镇痛效果良好,增加PRL的分泌,但对泌乳始动时间无明显影响。更多还原

【Abstract】 Objective To study the effect of labor analgesia with combined spinal-epidural block on serum prolactin(PRL).Methods Two hundred labor women were divided into two groups with 100 cases each.One hundred parturients were selected as labor analgesia group(group Ⅰ) and the(others) were as nature delivery group without analgesia(group Ⅱ).Bupivacaine 2mg and fentanyl 20μg were injected into the subarachnoid space while utero-cervical was opened to 2～3cm.Serum PRL level was measured with radioimmunoassay before analgesia and at 2,24h after labor in group Ⅰ.(Analgesia) effect and lactation were observed as well.Results The excellent pain relief was obtained in group Ⅰ.The serum PRL level at the time of the cervix fully opening in group Ⅰ was significantly higher than that in group Ⅱ.There were no significant differences in serum PRL level and the initial time of lactation at 2,24h after labor between the two groups.Conclusion Labor analgesia of combined spinal-epidural block is safe and effective with an increase of prolactin(secretion,) and has no(influence) on the initial time of lactation.更多还原