【摘要】 目的探讨孕妇血清标记物甲胎蛋白(AFP)和游离绒毛膜促性腺激素(F-βhCG)对孕中期(14~20周)孕妇进行产前筛查胎儿染色体异常及神经管缺陷的作用。方法应用时间分辨免疫荧光法检测血清指标,经过软件计算风险,对可能影响检测结果的因素,如孕妇年龄、体重、孕周等加以分析校正,对高风险孕妇进行羊水染色体检查及B超检查,每个孕妇随访追踪到胎儿出生。结果1543例孕妇中筛查出高风险孕妇79例,确诊神经管畸形2例,21-三体综合征1例,死胎2例;在1464例低风险孕妇中,出生缺陷4例结论孕中期二联筛查法作为产前筛查染色体异常及神经管缺陷有效,但也有一定的局限性。各实验室应建立自己的中位数值,提高筛查效率。更多还原

【Abstract】 Objective To discuss the functions of maternal serum AFP and free-βhCG in screening abnormal fetal karyotype and neural tube defects(NTD) in median gestation. Methods The dissociation-enhancement lanthanide fluoroimmunoassay was used to screen the serum AFP and free-βhCG. The software was used to calculate the risk and the factors, such as the maternal age, weight and gestation time. The amniocentesis and B-ultrasonic screening were used for the high risk pregnant women. All the pregnant women would be followed-up until the babies were born. Results 79 high risk pregnant women were found in 1 543 women, and 2 cases were diagnosed of NTD, 1 cases of Downs, 2 cases of dead fetal, 4 other disfigurements in low risk pregnant women. Conclusion The 2-united screening in median gestation has good function in screening abnormal fetal karyotype and NTD, while there are some limitations of this method. Thus every screening laboratory should have its own median to increase its screening efficiency.更多还原