节点文献
噬菌体随机展示肽库及其应用
Construction and application of phage display random peptide library
【摘要】 噬菌体随机展示肽库是一类利用丝状噬菌体发展起来的多肽文库。通过噬菌体展示技术,目前人们已能借助此类文库研究包括抗原决定簇的鉴定、疾病的诊断与治疗等许多领域的诸多关键性问题。本文简介此类文库的基本作用原理及应用。
【Abstract】 Phage display random peptide library is a kind of polypeptide library developed by filamentous bacteriophages. Recently, people have had the ability to do some research using the technology of phage display on identification of epitope sites on surface of antigens, the diagnosis and therapy of diseases, and in any other important fields. Here, the basic mechanism and the application of phage display random peptide libraries are briefly introduced.
【关键词】 噬菌体展示;
文库;
多肽;
抗原表位;
诊断;
靶向治疗;
疫苗;
靶向载体;
【Key words】 phage display; library; polypeptide; epitope; diagnosis; targated therapy; vaccine; targeted carrier;
【Key words】 phage display; library; polypeptide; epitope; diagnosis; targated therapy; vaccine; targeted carrier;
【基金】 国家自然科学基金(No:30400185)
- 【文献出处】 中国医学工程 ,China Medical Engineering , 编辑部邮箱 ,2005年05期
- 【分类号】Q789;
- 【被引频次】4
- 【下载频次】307