【摘要】 目的建立HPLC测定复方氯伪缓释胶囊两组分含量的方法。方法色谱柱为P latinum EPS C18(150 mm×4.6 mm,5μm);甲醇-水-二乙胺(830∶170∶0.25,用磷酸调pH 4.5)为流动相;检测波长为210 nm。结果盐酸伪麻黄碱与氯雷他定分别在94.6~144.6μg/m l与4.2~6.2μg/m l范围内呈良好线性关系,相关系数r分别为r=0.9995和0.9998。平均回收率分别为99.8%和98.5%(RSD分别为0.42%和1.13%)。结论该法简便、快捷、精密度高、重复性好,适用于本品的日常检测工作。更多还原

【Abstract】 Objective To establish a HPLC method of Pseudoephedrine Hydrochloride and Loratadine in the compound sustained-release capsules.Method The speration was performed on a Platinum EPS C₁₈（150 nm×4.6 nm,5 μm）.The mobile phase was consisted of methyl alcohol-water-ethylenediamene（830∶170∶0.25,pH 4.5 adjusted with H₃PO₄）.The flow rate was 1.0 ml/min and the detective wavelength was 210 nm.Column temperature was room temperature.Results It appears to have a good linearity within the concentration range of 94.6¹44.6 μg/ml for PSD（r=0.9995） and 4.2⁶.2 μg/ml for Loratadine（r=0.9998） respectively.The average recoveries were 99.8% and 98.5%,and relative standard deviation（RSD） was 0.42% and 1.13%.Conclusion The method was found to be simple,sensitive and accurate.更多还原