【摘要】 近年研究表明,TLRs家族是识别入侵病原体的主要先天免疫受体分子。TLRs信号能通过诱导促炎细胞因子的产生,并上调共刺激分子的表达迅速激活先天免疫,激活的先天免疫随后导致有效的获得性免疫的激活,因此它不仅激活先天免疫,而且最终激活获得性免疫。TLRs一旦与其特异配体结合,可激活信号转导级联,导致NFкB和MAPK的激活和免疫反应基因的表达。TLRs不仅能激活免疫细胞,而且还能激活肝细胞等其他细胞。此外,TLRs家族可能通过识别宿主产物参与了炎症病理,抑制TLRs作用的药物可能成为抗炎药,也可能成为治疗自体免疫疾病的药物。因此,不断加深对TLRs信号系统的理解是治疗各种病理状态的基础。更多还原

【Abstract】 Recently accumulating evidence has shown that innate immunity recognition of invading pathogens can be attributed mainly to the Toll-like receptor (TLR) family.TLR signaling can induce the production of proinflammatory cytokines and upregulate expression of costimulatory molecules to provoke rapid activation of innate immuniry. Activated innate immunity subsequently leads to effective adaptive immunity. It, thereby, activites not only innate but ultimately also adaptive immunity. It can mediate activation of many kinds of cells, such as immune cells, hepatocytes et al. Upon binding to its respective ligands, TLR can activate signal transduction cascades leading to activation of transcription factors and protein kinases such as NF-κB and MAPK, and expression of immune response genes. Besides,TLR family may be involved in the pathogenesis of inflammation via recognition of host products. Inhibition of TLR action may work as anti-inflammatory drugs, and possibly also as agents to treat autoimmune diseases.Thus,the increasing understanding of TLR system could be the basis for treating a variety of pathological conditions.更多还原