【摘要】 目的:探讨不同剂量氯氮平对男性精神分 裂症病人糖代谢的影响。方法:87例男性精神分 裂症病人分3组接受氯氮平治疗,低剂量组: 氯氮平<150mg·d-1;中剂量组:氯氮平150～300 mg·d-1;高剂量组:氯氮平>300mg·d-1。治疗 前和治疗6wk分别进行口服75g葡萄糖耐量试验 (OGTT),检测体重,并计算体重指数。结果:高剂 量组治疗6wk,OGTT1h和2h血糖水平和治疗前 比较均明显增高,经t检验,差异有显著意义(P<　目的:探讨不同剂量氯氮平对男性精神分 裂症病人糖代谢的影响。方法:87例男性精神分 裂症病人分3组接受氯氮平治疗,低剂量组: 氯氮平<150mg·d-1;中剂量组:氯氮平150～300 mg·d-1;高剂量组:氯氮平>300mg·d-1。治疗 前和治疗6wk分别进行口服75g葡萄糖耐量试验 (OGTT),检测体重,并计算体重指数。结果:高剂 量组治疗6wk,OGTT1h和2h血糖水平和治疗前 比较均明显增高,经t检验,差异有显著意义(P<0.01)。3组间治疗前后血糖水平经ANOVA分析,差异无显著意义(P>0.05)。高剂量组1hOGTT 异常者发生率明显高于低剂量组(P<0.05)。高剂 量组氯氮平治疗后体重增加明显(P<0.01)。3组 治疗前后未发现体重变化与OGTT异常存在明显的相关关系(P>0.05)。结论:高剂量氯氮平对男性精神分裂症病人的血糖、体重影更多还原

【Abstract】 AIM: To explore the effects of different doses clozapine on the glucose metabolism in male schizophrenics. METHODS: Eighty-seven male schizophrenics were randomly divided into three doses groups: the high dose group took clozapine over 300 mg·d -1; the middle one 150-300 mg·d -1, and the low one less than 150 mg·d -1. Before and after 6 wk treatment, all the patients were given oral glucose tolerance test (OGTT), with blood glucose measuring at 0,1,2,and 3 h. The body mass index (BMI) was also calculated. The data were analysed with t,χ2,q and ANOVA test. RESULTS: After 6 wk treatment, the blood glucose contents of the high dose group at the time-points of 1 and 2 h were higher than those of the baseline ones, respectively(P<0.01), while the other two groups showed no changes. Among three groups, the significant difference were only found between the high dose and the low dose groups (P< 0.05). The rate of impaired glucose tolerance (IGT) at the time-point of 1 h was higher in high dose group than in low dose group after treatment (P<0.05).Weight gains of the high dose groups were obviously increased after treatment(P<0.01). There was no significant relationship between the weight gains and the IGT in three groups before and after treatment. CONCLOSION: The high dose clozapine has stronger effects on the glucose metabolism and weights of male schizophrenics.更多还原