【摘要】 目的:探讨慢性肝病患者纤维化血清透明质酸(HA)、层粘蛋白(LN)、IV型胶原(IVC)、Ⅲ型前胶原(PⅢP)与肝组织病理检查即炎症活动程度和纤维化程度之间的关系。方法:对80例慢性肝病患者及30例正常对照者采用放射免疫法检测血清肝纤维化四项指标;对80例慢性肝病患者行肝组织穿刺作肝脏病理炎症分级和纤维化分期;然后将两者进行比较分析。结果:血清纤维化四项指标由G1~G4、S0~S4依次升高,但在各级及各期间升幅不完全一致;在反映肝脏炎症活动程度方面以HA上升最早,级间升幅较大;在反映肝组织纤维化程度方面PⅢP在S2期就明显升高;血清HA、LN、IVC、PⅢP水平与肝病分期及分级呈正相关。结论:透明质酸(HA)在反映肝脏炎症程度方面较敏感,Ⅲ型前胶原(PⅢP)在反映肝脏纤维化程度方面较敏感。肝纤维化血清学四项指标对了解肝脏炎症及纤维化程度有较高的临床价值。更多还原

【Abstract】 Objective:To investigate the relationship of serum hyaluronic ac id(HA),laminin(LN),type IV collagen(IVC),procolla-gen-III-peptide(PII IP)and liver inflammation and fibrosis,to evaluate its valuation in liver fibr osis noninjury check preliminarily.Methods:Liver biopsy was performed in80pation s with chronic hepatitis B for histological examination.Serum HA,LN,IVC,PⅢP w ere tested by EIA.Results:Serum HA,LN,IVC and PⅢP increased with inflammatory grades from G1to G4and the fibrosis stages from S0to S4,respec-tively.In infl ammatory grades HA increased first and with a higher degree than LN,IVC and PII IP did.In fibrosis stages PⅢP obviously increased fromthe stage S2than HA,LN a nd IVC.SerumHA,LN,IVC and PⅢP were positive correlated with the degrees of li ver inflammation and stages of liver fibrosis.Conclusion:HA was more sensitive t han LN,IVC and PⅢP in liver inflammation,PⅢP was more sensitive than HA,LN a nd IVC in liver fibrosis.Serum HA,LN,IVC and PⅢP had more useful clinical val uation in liver inflammation and liver fibrosis.更多还原