【摘要】 目的探讨多囊卵巢综合症(PCOS)患者胰岛素抵抗与脂代谢和排卵的关系。方法测定25例PCOS患者和15例非内分泌因素不孕症妇女的性激素、血脂、胰岛素(Ins)水平,其中PCOS患者进行口服糖耐量试验(OGTT)。OGTT提示胰岛素抵抗(IR)者给予罗格列酮(4mg/d)治疗,并促排卵药物治疗,3月后复测上述血清指标。结果PCOS患者经治疗后血清Ins、胆固醇、甘油三酯、高密度脂蛋白水平显著降低,排卵率增加,IR状态改善。结论血脂异常是PCOS患者临床表现之一,IR和高胰岛素血症是PCOS患者血脂异常的重要原因。罗格列酮阻断IR对PCOS发展的促进作用,改善PCOS的血脂紊乱,增加排卵的发生。更多还原

【Abstract】 Objective To investigate the effects of roslglitazone on polycystic ovary syndrome (PCOS) and its relationship to insulin-resistance (IR), blood-adipose metabolism and ovulation.Methods Serum levels of sex hormone, blood-adipose, fasting insulin were determined in both PCOS group and controls (fifteen infertility patients) and glucose tolerance test in PCOS groups. Roslglitazone and acceleration ovulation therapy were gived (4mg/d) in PCOS with IR. Results Mean (±SEM) concentrations of insuin, total cholesterol, triglyceride and high density lipoprotein were decreased and ovulation rate were rised significant in PCOS treated with roslglitazone. Conclusion Disorder metabolism of blood-adipose is a clinical situation of PCOS and it principal caused by IR and hyperinsulinemia. The disorder can be treated by roslglitazone.更多还原