【摘要】 目的　建立测定人血浆中佐米曲普坦血药浓度的液质联用方法 ,研究佐米曲普坦在中国健康志愿者体内药代动力学。方法　 2 0名健康男性志愿者口服单剂量佐米曲普坦 5mg,给药后 ,连续采集血样至 2 4h ,分离得到血浆 ,采用液质联用分析佐米曲普坦血药浓度。结果　佐米曲普坦药时曲线符合口服吸收有滞后时间的二房室模型 ,Tmax1 .6 0± 0 . 2 4h ,Cmax9 .73±1. 4 3ng·mL-1 T1/ 2α1. 72± 0 .4 6h ,T1/ 2 β4 . 5 2± 0 . 97h ,AUC0 -t5 5 . 5 9± 5 . 12ng·mL-1·h。结论　本方法操作便捷 ,灵敏度高 ,为其血药浓度测定及药代动力学研究提供了方法学基础。更多还原

【Abstract】 Aim To establish a new and sensitive HPLC-MS met ho d for the determination of zolmitriptan in human plasma and study the pharmacoki netics of zolmitriptan in healthy volunteers. Methods A sin gle oral dose of 5 mg of zolmitriptan tablet was given to 20 healthy male volunteers . After dosing, blood samples were collected for a period of 24 h, and zolmitrip tan concentration in plasma was analyzed by HPLC-MS. Results T he plasma concentration-time course fitted well a two-compartment open model with a lag time, giving the following pharmacokinetic parameters: T max 1.60±0.24 h, C max 9.73±1.43 ng·mL -1. T 1/2α1 .72±0.46 h, T 1/2β 4.52±0.97 h, and AUC 0-t 55.59±5.12 n g ·mL -1·h. Conclusion The improved analytical method for zolmitriptan is rapid,sensitive and suitable for application to pharmacokineti c studies and routine determination of numerous samples.更多还原