【摘要】 目的观察益气活血法对多发脑梗死性痴呆模型大鼠脑神经细胞凋亡调控基因的影响。方法采用颈内动脉注射血栓的方法,复制多发脑梗死性痴呆大鼠模型,观察益气复智颗粒24.84、12.4、6.21g/kg灌胃对实验动物脑组织bax和bcl-2基因蛋白表达及bax/bcl-2的影响。结果益气复智颗粒能抑制脑缺血后脑组织中bax基因蛋白的过度表达,并明显降低bax/bcl-2的比值。结论益气活血法及益气复智颗粒具有较好的调控脑缺血后基因蛋白表达的能力,可能是其抑制脑神经元凋亡的主要机理之一。更多还原

【Abstract】 Objective To observe the effect of Benefiting vital Qi and Promoting Blood Circulation in affecting gene expression related to appotosis of neuron in rat models with multiple infarctional dementia.Methods Internal carotid injection method was used to make rat models with multiple infarctional dementia and observations were made to observe effects in affecting expression of gene bax,gene bcl-2 and the ratio of bax to bcl-2 in the brain tissue of rat by small,moderate and large concentration of Yiqi Fuzhi Granule.Results Yiqi Fuzhi Granule could inhibit the overexpression of bax gene in brain tissue after brain ischemia.Conclusion Benefiting vital Qi and Promoting Blood Circulation and Yiqi Fuzhi Granule could regulate expression of gene after brain ischemia.This may be the main mechanism of resisting the appotosis of neuron.更多还原