【摘要】 目的观察七味白术散对人轮状病毒(HRV)感染乳鼠血清干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)的影响,探讨七味白术散治疗HRV感染的作用机制。方法NIH乳鼠经口建立感染模型,按窝随机分为3组,并分别灌服生理盐水(NS)、七味白术散、病毒唑,正常组灌服NS,连续7d。采用ELISA法检测HRV感染乳鼠血清IFN-γ、TNF-α。结果七味白术散组血清IFN-γ高于模型组,TNF-α低于模型组(P<0.05)。结论七味白术散能提高HRV感染乳鼠血清IFN-γ,下调血清TNF-α,显示一种新的免疫调节效应。更多还原

【Abstract】 Objective To study the influence of Qiweibaizhu Powder on the serum IFN-γ and TNF-α levels of suckling mice infected with HRV and to explore the mechanism of Qiweibaizhu Powder in the treatment of HRV infection. Methods The model of NIH suckling mice infected with HRV orally were established and were randomly divided into 3 groups by home. The normal control group was treated with NS, and the other groups were treated with NS, Qiweibaizhu Powder, Ribavirin respectively for 7 days. The serum IFN-γand TNF-α levels of suckling mice infected with HRV were observed by the techniques of ELISA. Results The serum IFN-γlevels in the group treated with Qiweibaizhu Powder was higher than that in the model group, the serum TNF-α levels was lower than that in the model group (P<0.05). Conclusion Qiweibaizhu Powder can enhance the serum IFN-αlevels of sukling mice infected with HRV, and reduce the serum TNF- α levels, which is showing a new immunoregulatory effect.更多还原