【摘要】 目的:探讨胰岛索抵抗与C-反应蛋白(CRP)及冠状动脉病变之间的关系。方法:连续收集冠状动脉造影证实至少有一支血管狭窄≥50%的113名患者作为研究对象,均行口服葡萄糖耐量(OGTT)试验及CRP、胰岛素测定。以自我平衡模型分析法(HOMA)指数为评价胰岛素抵抗程度指标,对CRP及冠状动脉病变程度行相关分析。结果: 随着冠状动脉病变程度的增加,CRP水平逐渐增加,胰岛素抵抗程度逐渐增加。胰岛素抵抗与CRP及冠状动脉病变程度具有明显相关性(P均<0.01)。结论:胰岛素抵抗可能是动脉粥样硬化疾病的基础,在冠心病的预防和治疗中要重视降低胰岛素抵抗。更多还原

【Abstract】 Objective:To investigate the correlation among insulin resistance (IR) and C reaction protein (CRP) as well as the severity of coronary lesion. Methods:A total of 113 patients with least one vessel had angiostegnosis ≥50% by coronary arteriongraphy were study objects. Oral glucose tolerance test (OGTT) was performed and blood lipid, plasma insulin were detected in all patients. IR was assessed by homeostasis model. Results: The level of IR was cor-rlated with the levels of C reaction protein, serum glucose, insulin, hypertension, serum triglycerides, high density lipoprotein cholesterol and severity of coronary lesions in coronary artery disease (CAD) (P<0.05-<0.01). Conclusion:Insulin resistance may be the CAD basis;it must be decreased for the CAD prevention and cure.更多还原