【摘要】 目的探讨妊娠高血压综合征(妊高征)患者血管内皮细胞的改变及其在妊高征血栓前状态(PTS)中的诊断意义。方法应用 ELISA 法及发色底物法测定妊高征患者血中血管性血友病因子(vWF)、组织型纤溶酶原激活物 (tPA)及纤溶酶原激活物抑制剂-1(PAI-1)活性。结果妊高征患者 vWF、tPA、PAI-1 较正常非孕组明显升高,差异有统计学意义(P＜0.05或 P＜0.01)；与正常晚孕组比较,妊高征及各组患者 vWF、PAI-1 活性显著增高(P＜0.05或 P＜ 0.01),且病情越重增高越明显；而 tPA 则无明显改变。中、重度妊高征组血浆 vWF 与 PAI-1水平呈直线正相关关系(r =0.723,P＜0.5；r=0.765,P＜0.05)。结论妊高征患者由于内皮细胞功能异常,导致了凝血功能及纤溶抑制功能亢进,因此测定血浆中 vWF 和 PAI-1水平,及时发现血管内皮细胞损伤,对于指导临床诊断及治疗具有重要意义。更多还原

【Abstract】 Objective To explore the changes and clinical significance of plasma von Willebrand factor (vWF),tissue-type plasminogen activator(tPA)and plasminogen activator inhibitor-1(PAI-1)levels in pa- tients with induced pregnancy hypertension.Methods Plasma vWF、tPA and PAI-1 were determined by ELISA and chromogenic assay respectively in 50 non-pregnancy(control group),50 normal pregnancy women (normal pregnancy group)and 85 patients with preganacy induced hypertension(PIH group).Results In normal late pregnancy group and PIH group vWF,tPA and PAI-1 were significently higher than those of con- trol group;In PIH group vWF and PAI-1 were significently higher than those of normal pregnancy group but tPA did not.There was a positive correlation between the plasma vWF and PAI-1 levels in moderate and severe PIH group(r=0.723,P＜0.05;r=0.765,P＜0.05 respectively).Conclusion There was endothelial damages in patients with induced pregnancy hypertension.The levels of plasma vWF and PAI-1 may be two in- dices for the surveillance of PIH.It is important for the diagnosis and therapy of PIH to oberserve the changes of their levels.更多还原