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紫色甘薯多糖对荷瘤小鼠抗肿瘤活性的影响

Effect of Polysaccharide in Purple Sweet Potato on the Antitumor Activity of Cancer Bearing Mice

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【作者】 叶小利; 李学刚; 李坤培;

【Author】 YE Xiao-li~1, LI Xue-gang~2, LI Kun-pei~1 1. School of Life Science, Southwest China Normal University, Chongqing 400715, China; 2. Institute of Pharmaceutical Resource Chemistry, Southwest Agricultural University, Chongqing 400716, China

【机构】 西南师范大学生命科学学院; 西南农业大学药用资源化学研究所; 西南师范大学生命科学学院 重庆400715; 重庆400716; 重庆400715;

【摘要】 以荷瘤S180小鼠为实验对象, 研究了紫色甘薯多糖对S180荷瘤小鼠肿瘤的体内抑制、免疫器官的影响. 结果表明: 紫色甘薯多糖对S180荷瘤小鼠的抑瘤率可达40%左右(P<0 01); 低剂量的紫色甘薯多糖与5 氟尿嘧啶(5 FU)配伍使用, 能提高荷瘤小鼠抑瘤率, 对5 FU所致的荷瘤小鼠胸腺、脾脏质量萎缩有明显的保护作用, 对白细胞的减少有一定的拮抗作用.

【Abstract】 The antitumor effect of polysaccharide in purple sweet potato on the Sarcoma 180 (S (180)) bearing mice was observed. The inhibitory rate to S (180) tumor and immune function of mice was determined. Results showed that polysaccharide extracted from purple sweet potato had markedly effect of inhibitory tumor on the cancer S (180) bearing mice, and its inhibitory rate would be 40% (P<0. 01); the mixture therapy group of low dose polysaccharide (200mg/kg) and 5-fluorine uracil (5-FU) would inhibit tumor, and had obviously protective effect on the thymus and spleen weights atrophy resulted from 5-FU, and had antagonism of the decrease in white cell amount.

【关键词】 多糖; 紫色甘薯; 抗肿瘤;
【Key words】 polysaccharide; purple sweet potato; antitumor activity;
【基金】 重庆市科委资助项目(2003 8116和2003 7684).
  • 【文献出处】 西南师范大学学报(自然科学版) ,Journal of Southwest China Normal University(Natural Science) , 编辑部邮箱 ,2005年02期
  • 【分类号】R73-36
  • 【被引频次】61
  • 【下载频次】375
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