【摘要】 目的探讨谷胱甘肽硫转移酶(GST)T1基因多态、吸烟与大肠腺瘤易感性的关联。方法用多重PCR法检测174例大肠腺瘤患者和101例健康人GSTT1基因多态性。结果管状腺瘤、绒毛状腺瘤及混合型腺瘤患者分别与健康人比较,GSTT1空白基因型频率的差异均无显著性;重度吸烟的管状腺瘤患者与健康对照比较,其差异有显著性(较正0R=2.67,95%CI=1.12~6.37,P=0.027)。结论GSTT1空白基因型与大肠腺瘤的危险性无关,重度吸烟且携带GSTT1空白基因型的个体患大肠腺瘤的危险性明显上升。更多还原

【Abstract】 Objective To analyze the relation of glutathione S-transferase T1(GSTT1) and smoking with the risk of colorectal adenoma. Methods Using multiplex PCR, the GSTT1 genetic polymorphisms for 174 colorectal adenomas and 101 healthy persons as control were detected. Results The differences of the frequency of GSTT1 null genotype between the tubular adenomas,villous adenomas or tubulovillous adenomas and the controls were all not statistically significant,but this genotype was significantly more common among colorectal tubular adenoma patients with severe-smoking in comparison with controls who had also severely smoking(adjusted 0R=2.67, 95%CI=1.12~6.37, P =0.027). Conclusion GSTT1 null genotype is no related to risk of colorectal adenoma, but in individuals with GSTT1 null genotype and also being severe-smoker,the risk of colorectal tubular adenoma will be obviously elevated.更多还原