【摘要】 1日龄艾维茵肉鸡健雏200只随机分为4组, Ⅰ组( 基础日粮,Zn 100 mg/kg)、Ⅱ组(基础日粮+Zn 1 400mg/kg)、Ⅲ组(基础日粮+Zn 1 900 mg/kg)和Ⅳ组(基础日粮+Zn 2 400 mg/kg),试验期 7 周。病理组织学观察可见免疫器官的淋巴细胞减少,淋巴滤泡形成较少,其皮质变薄、髓质增宽并可见髓质部淋巴细胞减少。淋巴器官发育和外周血淋巴细胞的分裂增殖受抑,外周血T淋巴细胞的成熟率显著降低并引起其亚群 CD4 、CD8 数量和组成的变化,导致机体细胞免疫和体液免疫功能的降低;雏鸡红细胞C3b受体花环率下降和免疫复合物花环率升高,引起红细胞免疫黏附功能降低。结果表明,日粮高锌可致雏鸡免疫功能受损。更多还原

【Abstract】 The experiment was conducted to study the effects of high zinc on immune function in chicken. 200 one-day-old Avian broilers were randomly divided into four groups and fed on diets as follow: basic diet （Zn 100 mg/kg, control [Ⅰ]） and high zinc diets （Zn 1 500 mg/kg [Ⅱ], 2 000 mg/kg [Ⅲ], 2 500 （mg/kg） [Ⅳ]） for seven weeks. The chicken in groups Ⅱ, Ⅲ and IV grew very slowly. At the same time, lymphocytes of the thymus, bursa of Fabricius and spleen were significantly depleted, degenerated and necrotic histopathologically. The weight and growth index of lymphoid organs,proliferating index of lymphocytes, the ANAE⁺ ratio of peripheral blood lymphocytes and erythrocyte C₃bRR ratio markedly decreased and ICR ratio increased markedly in high zinc groups when compared with control group. The above mentioned results indicated that proliferations of lymphocytes were impaired by high zinc.更多还原