【摘要】 目的:探讨雌激素受体(ER)、孕激素受体(PR)在子宫内膜良恶性组织中的表达及其临床意义。方法:采用LSAB法对33例子宫内膜癌、39例子宫内膜单纯型增生、31例子宫内膜非典型增生及31例正常子宫内膜标本进行ER、PR的检测。结果:ER、PR在子宫内膜单纯型增生(46.15%、66.67%)、非典型增生(48.38%、64.52%)及子宫内膜癌(60.61%、60.61%)中的阳性表达率明显高于正常子宫内膜(19.35%、25.82%),P<0.05。且ER、PR阳性表达强度在单纯型增生、非典型增生、子宫内膜癌与正常内膜之间差异有统计学意义(P<0.05)。ER阳性表达率在子宫内膜癌组织分化之间的差异有统计学意义(P<0.05)。但ER、PR阳性表达率在其年龄、临床分期及绝经情况方面的差异均无统计学意义。结论:子宫内膜癌发生发展中可出现ER、PR异常表达,为临床内分泌治疗提供理论依据。更多还原

【Abstract】 Objective: To study the expression of estrogen and progesterone receptors(ER、PR) in benign and malignant lesions of endometrium,and study it’s clinical significance.Methods: The expression of ER and PR in 33 cases of endometrial carcinoma,39 cases of endometrial cystohyperplasia,31 cases of atypical endometrial hyperplasia and 31 cases of normal endometrium in control group were detected by using LSAB immunohistochemical method. Results: There were significant differences of ER,PR expression between endometrial cystohperplasia(46.15%,66.67%),Atypical growth of endometrium((48.38%,) 58.32),(endometrial) carcinoma(60.61%,60.61%) and normal endometrial tissue(19.35%,25.81%)(P<(0.05)).The expression of ER in endometrial carcinoma was significatly different between high grade and low grade (P<0.05),but no relationship with its clinical stages,ages and conditions of menopause(P<(0.05)).Conclusion: The abnormal expression of ER,PR in endometrial disease plays an important role in occurrence and development of endometrial carcinoma,and may be a refer index in guiding clinical endocrinotherapy of endometrial carcinoma.更多还原