【摘要】 目的:评价卡维地洛治疗各级原发性高血压病的临床疗效、安全性及副作用,并对汉族、哈萨克族(哈族)两民族患者的临床疗效进行对照分析。方法:选择汉、哈族各级原发性高血压病患者各34例,均服用卡维地洛(10 mg/d)进行降压治疗,2周后疗效不满意即加量至50 mg/d,服药2、4、8、12周后分别观察血压、心率及副反应情况。结果:治疗12周后,汉族患者收缩压及舒张压的降压幅度分别为18.5%、16.3%,哈族患者收缩压及舒张压的降压幅度分别为195%、17.3%,与用药前相比差异有统计学意义(P<0.01)。治疗8周后汉族患者心率不再变化,哈族患者心率呈进一步下降趋势,12周后两者心率变化差异有统计学意义(P<0.01)。汉族和哈族患者用药前后血糖、血脂、肝肾功能均无明显变化。结论:卡维地洛对汉、哈族患者各级原发性高血压均有较好治疗作用,副作用少,但哈族患者应用时应注意监测心率变化。更多还原

【Abstract】 Objective: To assess the effect and reliability together with difference between Han and Kazak people of carvedilol in treatment of essential hypertension. Methods: Thirty-four Han and Kazak patients with all-class essential hypertension have been enrolled to take carvedilol 10 mg per day, or accept a dose of 50 mg per day after 2 weeks, to observe blood pressure, heart rate and side effect after 2, 4, 8 and 12 weeks. Results: After 12 weeks of administration, systolic and diastolic blood pressure of Han patients decreased 18.5%、16.3% compared to that before treatment, systolic and diastolic blood pressure of Kazak patients decreased 19.5%、17.3% compared to that before treatment respectively (P<0.01), there had no difference between the two groups (P>0.05), but heart rate of Han patients show obvious difference from Kazak after treatment of 12 weeks (P<0.05). Few side effects have been detected during the process. Conclusion: Carvedilol have nice effect on both Han and Kazak essential hypertension patients, meanwhile suffer few side effect, but heart rate should be monitor in Kazak patents.更多还原