【摘要】 目的:探讨罗勒水提取物对二磷酸腺苷(ADP)、凝血酶诱导的大鼠血小板聚集的影响。方法:60只Wistar大鼠随机分为6组:生理盐水组、8.8mg/kg阿司匹林组、4.7mg/kg丹参滴丸组及200、300、500mg/kg罗勒水提取物3个剂量组,采用比浊法测定各组大鼠ADP、凝血酶诱导的血小板聚集率和抑制率。结果:与生理盐水组相比,罗勒水提取物3个剂量对ADP和凝血酶诱导的血小板聚集有明显的抑制作用(P均<0.05),作用强度与阿司匹林相似,与丹参滴丸组相比差异无统计学意义(P>0.05),其中200、300、500mg/kg罗勒水提取物对ADP、凝血酶诱导的大鼠血小板聚集率分别为42.93%、53.81%、60.16%、60.43%和55.34%、59.41%。结论:罗勒水提取物对ADP、凝水酶诱导的大鼠血小板聚集具有抑制作用。更多还原

【Abstract】 Objective: To study the effects of aqueous extract of ocimum basilicum on platelet aggregation. Methods: ADP and thrombase were used to induce platelet aggregation and plate function was evaluated by turbidimetry to observe ocimum basilicum effects on platelet aggregation. Results: ocimum basilicum (200,300,500 mg/kg) inhibits platelet aggregation by ADP and thrombase: ocimum basilicum 200 mg/kg had an inhibition rate of 42.93% and 53.81% of platelet aggregation by ADP and thrombase, respectively. Inhibition rates for ocimum basilicum at 300 mg/kg were 60.16%, 60.43%, while ocimum basilicum at a dose of 500 mg/kg inhibits platelet aggregation by ADP and thrombase were 55.34%, 59.41%, respectively. Conclusion: ocimum basilicum possesses an inhibitory effect on platelet aggregation induced by ADP and thrombase.更多还原