【摘要】 目的:探讨血清中可溶性白细胞介素2受体(sIL-2R)水平、肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平及其在检查丙型肝炎病毒感染中的意义。方法:应用ELISA方法检测42例正常人以及87例丙型肝炎患者血清中sIL-2R、TNF-α和IL-6水平。将病人分为3组:A组:抗HCV-Ab(-),HCVRNA(+)。B组:抗HCVAb(+),HCVRNA(-)。C组:抗HCV-Ab(+),HCV-RNA(+)。结果:3组病人血清中sIL2R、TNF-α和IL-6水平较正常人均明显增高(P<0.01),3组间sIL-2R、TNF-α和IL-6水平比较,除A、C组外,A、B组之间、B、C组之间差异均有统计学意义(P<0.01)。结论:sIL-2R、TNF-α和IL-6水平的检测可作为丙型肝炎诊断的指标之一。更多还原

【Abstract】 Objective: To evaluate the levels of soluble interleukin-2 receptors (sIL-2R), tumor necrosis factor alpha(TNF-α) and interleukin-6 in serum and its value of examination for hepatitis C. Methods: The levels were detected in serum of 87 cases with hepatitis C and 42 normal persons by using ELISA method. In addition, the authors divided all of the patients into three groups that included the group A 〔HCV-Ab(-), HCV RNA(+)〕, the group B 〔HCV-Ab(+),HCV RNA(-)〕 and the group C 〔HCV-Ab(+),HCV RNA(+)〕. Results: The results showed that the levels of sIL-2R, TNF-α and IL-6 were significantly increased in serum of 87 patients and each group (P<0.01) as compared with the control group. The remarkable difference still happened in comparison with patient’s groups each other except between A and C. Conclusions: The authors, therefore, think that to survey the levels of sIL-2R, TNF-α and IL-6 may be regarded as an indicator to diagnose hepatitis C.更多还原