【摘要】 目的: 研究草棉花花瓣不同提取物FGF Ⅰ、FGF -Ⅱ对小鼠免疫性肝损伤的保护作用。方法:采用卡介苗(BCG)+脂多糖(LPS)造成免疫性肝损伤动物模型,观察本品对小鼠血清ALT、AST 活性及肝组织匀浆SOD、MDA、GSH PX、NO水平的影响,并观察肝组织病理学改变。结果: FGF -Ⅱ可明显降低小鼠血清中ALT、AST活性,同时能减少肝匀浆MDA、NO含量,并能使降低的肝匀浆SOD、GSH PX活性升高。FGF -Ⅱ小剂量可使肝脏脏器系数降低。FGF -Ⅰ不同剂量可以降低ALT活性,但不能降低AST活性,大剂量可降低MDA含量,而对肝组织匀浆其它指标FGF- Ⅰ不同剂量均没有作用。结论: FGF -Ⅱ有明显的保肝作用,FGF- Ⅰ虽有一定的保肝作用,但效果不如FGF- Ⅱ。更多还原

【Abstract】 Objective: To investigate the hepatoprotective effect of Flos Gossypium Flavonoid (FGF-Ⅰ, FGF-Ⅱ) on immunological liver injury in mice. Method: The models of hepatic damage of immunity were induced by BCG+LPS. The ALT、AST level in serum and MDA、 NO content, SOD、 GSH-PX activities in liver homogenate, the coefficient of liver were assayed and dimensions of hepatic damage in the histopathology were observed. Results: FGF-Ⅱ(70, 35 mg/kg) was found to significantly decrease the serum transaminase activities. Meanwhile, FGF-Ⅱ also decreased MDA, NO content and prevented the reduction of SOD , GSH-PX activities in liver homogenate and FGF-Ⅱ (35 mg/kg) decreased coefficient of liver. FGF-Ⅰ (70, 35 mg/kg) was found to decrease the serum ALT, but cannot decrease the serum AST, FGF-Ⅰ (70 mg/kg) also decreased MDA, but other index of liver homogenate FGF-Ⅰ (70, 35 mg/kg) was ineffective. Conclusion: FGF-Ⅱ show significant protective action on immunological liver injury in mice. FGF-Ⅰ has less effect on protecting liver than FGF-Ⅱ, though FGF-Ⅰ has some effects.更多还原