【摘要】 目的　探讨D二聚体在川崎病急性期的变化和对冠状动脉损伤(CAL )的诊断价值。方法　检测川崎病(KD)组(n=4 8)治疗前后及对照组(n=30 )患儿血浆D二聚体浓度,分析D二聚体浓度与冠状动脉损伤的关系。结果　KD组血浆D二聚体浓度明显高于健康对照组(P<0 .0 5 ) ;KD组治疗3周后D二聚体水平低于治疗前(P<0 .0 5 ) ;CAL组D二聚体水平治疗前、治疗后均高于无CAL组,(P<0 .0 5 )。结论　D二聚体浓度对KD患儿急性期CAL有诊断价值;阿司匹林治疗能有效改善KD患者的血液高凝状态,从而减少KD患儿心血管并发症的发生。更多还原

【Abstract】 Objective To explore the change of plasma D-Dimer and its value in diagnosing coronary artery injury in children with Kawasaki disease(KD) of acute stage. Methods The level of plasma D-Dimer was determined in 48 children with KD before and after treatment and 30 healthy children, respectively to survey the relationship between the level of plasma D-Dimer and coronary artery injury. Results The level of plasma D-Dimer in KD patients was significantly higher than that in the control ones(P<0.05). In KD patients, the level of D-Dimer before treatment was markedly higher than that after treatment(P<0.05). The level of D-Dimer in KD patients with coronary artery injury(CAL) was distinctly higher than that without CAL(P<0.05),but the difference were not evident after two weeks’ treatment(P>0.05). Conclusion The determination of D-Dimer will be contributive to the diagnosis of CAL in children with KD of acute stage. The concomitant high coagulation stage can be effectively treated with aspirin and accordingly lower the occurrence of complications of angiocardiopathy.更多还原