【摘要】 目的通过对FH及FP两组化疗方案在胃癌化疗中的疗效观察,了解DDP和5-FU联合用药存在的生物化学相互修饰在临床实际工作中应用价值。方法选择经病理学检查证实的胃癌病人60例,随机分两组,每组30例。分别应用FH方案及FP方案进行化疗四周期,采用WHO推荐的实体瘤疗效评价标准及毒性反应分级标准对两组的疗效进行评定。结果从两组方案的疗效看有效率相近,无显著差异,FP方案不良反应较轻,易被大多数病人特别是中晚期肿瘤病人所接受,有望成为胃癌治疗中的主要化疗方案。更多还原

【Abstract】 OBJECTIVE Throughthe observation of the clinical effect of FH and FP chemotherapy in stomach cancer,the practical value of the biochemical mutual modification of DDP and 5-FU in combining drug was known.METHOD 60 cases of stomach cancer were randomized into two group.30 patients in each group.The two group had been treated differently with FH or FP chemotherapy for4 cycle,the clinical and side effect of the two group were valued with the WHO recommended value standard.RESULT The response rats of FH group and FH group were 53.3%and 57.7%,there were no significant difference statistically between them(P > 0.05).The side effect of FP chemotherapy was slighter than FH,and the former chemotherapy was easy to accepted by patients,especially by middle and late phase patients.It was possible for FP to become the main chemotherapy in stomach cancer treatment.更多还原