【摘要】 目的介绍国内外提高蛋白质与多肽类药物肺部给药系统生物利用度的方法及其作用机制的最新研究进展。方法对国内外最新发表的相关文献进行分析、整理和综合。结果吸收促进剂、酶抑制剂及脂质体均可使蛋白质及多肽类药物的肺部吸收明显提高,甚至达到治疗所需的生物利用度。结论蛋白质及多肽类药物的肺部给药系统具有广阔的应用前景。更多还原

【Abstract】 OBJECTIVE To review recent advances in increasing the bioavailability of therapeutic protein and peptide drugs,and their mechanism of action and effectiveness.METHODS To collect and analyse the latest newly published articles. RESULTS Absorption enhancer,protease inhibitors and liposomes have their potential to achieve substantial bioavailability of protein and peptide drugs from pulmonary administration.CONCLUSION Pulmonary delivery for protein and peptide drugs has grand prospect.更多还原