【摘要】 目的观察草酸铂(L-OHP)联合持续静脉注射5-FU为主方案治疗晚期胃癌近期疗效观察。方法晚期胃癌23例。采用L-OHP75mg/m2加葡萄糖注射静脉注射第1天、第8天,甲酰四氢叶酸钙(CF)100mg/m2静滴第1~5天,足乙叶苷(Vp-16)100mg静滴第1~3天,5-FU500mg/m2持续静脉滴注120h,每3~4周,2个周期化疗后进行临床评价。结果完全缓解(CR)2例,部分缓解(PR)12例,总有效率60.9%,不良反应主要为Ⅰ、Ⅱ度白细胞下降及Ⅰ度周围神经毒性。结论L-OHP联合持续静脉注射5-FU为主方案治疗晚期胃癌疗效好,不良反应轻,患者能耐受,是一种安全有效的化疗方案。更多还原

【Abstract】 OBJECTIVE To observe the short-term respose of combination infusion of 5-FU with oxaliplatin (L-OHP) in advanced gastric cancer. METHODS 23 patients with advanced gastric cancer using randomized method. L-OHP:75mg/m~2, iv infusios 3 hours,d1,8; LV 100mg/m~2,iv infusion d1-5;VP-16:100mg,iv infusion d1-3;5-FU 500mg/m~2 mcontinuous infusion 120 hours 3-4 weeks is a cycle.2 cycles were carried out. RESULTS The response rate was 60.9%(14/23).The major toxic effect were myelosuppression(grade Ⅰ-Ⅱ)and peripheral neuropathy toxicty(grade Ⅰ). CONCLUSION L-OHP+CF+VP-16+5-FU regimen is effective and well tolerable for advanced gastric cancer.更多还原