【摘要】 目的了解引导组织再生治疗术(GTR)及碱性成纤维细胞生长因子(b-FGF)是否能够促进犬Ⅱ度根分叉病变牙周组织的再生。方法将六只杂种犬的下颌双侧第二、三、四前磨牙制备慢性Ⅱ度根分叉病变模型后,随机分成两组,每组三只动物。每组中一只动物一侧进行GTR治疗,另一侧只进行翻瓣术治疗;另一只双侧都进行GTR+b-FGF治疗;剩下的一只一侧进行GTR治疗,另一侧进行GTR+b-FGF治疗。分别于术后第6、8周进行形态学和组织学观察。结果与翻瓣术组对比,GTR组和GTR+b-FGF组都有明显的牙周组织再生;而GTR组和GTR+b-FGF组之间牙周组织再生的量没有明显的差别。结论GTR能够促进犬Ⅱ度根分叉病变牙周组织的再生,但单纯应用喷洒法使用b-FGF于牙周组织再生术中难以发挥其应有的疗效。更多还原

【Abstract】 Objective To evaluate the effect of guided tissue regeneration (GTR) and basic fibroblast growth factor (b-FGF) on the wound healing and regeneration of periodontal tissues in mongrel dogs.Methods Six mongrel dogs, which grade Ⅱ furcally-involved teeth (6-millimeter in height, 6-millimeter in width, 3-millimeter in depth) had been created surgically in all 2 nd,3 rd and 4 th premolar teeth of mandibular area. Six weeks after they were divided into two groups, 3 dogs in each group. One had its one side of the jaws been treated by GTR, the other side was treated by flap operation therapy; another one had its all experimental teeth been treated by GTR plus b-FGF; the last one had its one side of the jaws been treated by GTR, the other side was treated by GTR plus b-FGF. The animals were sacrificed at 6 and 8 weeks, and routine histologic procedures were performed.Results Compared to the three different treatments, there were more periodontal regeneration tissues in the GTR and GTR plus b-FGF treatment groups than flap operation therapy groups. But, the difference between GTR and GTR plus b-FGF treatment groups was not statistically significant.Conclusion Repairing of periodontal defects using the e-PTFE membranes appears to be possible. However, a single-dose application of b-FGF by insufflate appears ineffective.更多还原