【摘要】 目的探讨采用内置式三焦点牵引器在犬下颌骨骨段缺损功能重建中牵引成骨的特点、规律。方法使用内置式三焦点牵引器对4只成年犬下颌骨骨段缺损进行牵引成骨重建。制作3cm下颌骨缺损区,同期植入内置式三焦点牵引器。牵引间歇期8天,牵引速度0.5mm×2次/天,稳定期3个月。结果下颌骨牵引成骨约30mm,牵引成骨过程中无感染、成骨不良等并发症。牵引完成后第3个月X线片、组织学观察及扫描电镜观察均可见新生骨的形成,新生骨的形态、组织结构接近正常下颌骨。结论三焦点牵引成骨技术重建的颌骨形态、组织结构和功能接近正常颌骨,牵引成骨区和压力成骨区局部应用rh-BMP2可以促进新骨的形成及钙化。更多还原

【Abstract】 Objective To apply internal trifocal distraction osteogenesis in a canine model of mandibular segmental defects and to study the characteristics of regenerating bone in the functional mandible reconstrction.Methods The internal trifocal distractor was used to reconstruct the mandibular segmental defects of 4 canine model. Mandibular segmental defects in the canine models were established and an internal trifocal distractor was implated at the same time. After 8 days of latency period, trifocal DO was started at a rate of 0.5 mm×2 times per day at each distraction region. The regenerating bone was examined by X-ray and histological method during stages of distraction osteogenesis. Distraction was continued for 15 days. At the end of distraction, the distractor was left in place as an internal fixator for 12 weeks.Results The mandibular defect was successful reconstructed for 30 mm in length of 15 days without any complications. The regenerated bone was confirmed based on the presence of new bone deposit along the mandibular defect by the X-ray, histologic examination, immunohistochemical stain, and scanning electron microscope(SEM). Compression osteosynthesis occured at the region of transport disk union. At 12 weeks after the distraction, the entire regenerate bone was showed near normal in and the morphology and in the density.Conclusion Mandibular segmental defect can be reconstructed successfully by trifocal distraction osteogenesis. The whole gap was filled with new bone and the union of two transport disk was occurred at 12 weeks after the distraction.更多还原