【摘要】 背景:成纤维细胞生长因子生物蛋白海绵对创伤性溃疡修复的作用已经受到关注。目的:观察成纤维细胞生长因子生物蛋白海绵对创伤性溃疡的修复作用及可能发生的不良反应。设计:分组对比观察。单位:暨南大学医学院生理教研室。对象:选择2004-03/05暨南大学第一附属医院收治的皮肤创伤性溃疡患者40例,排除糖尿病及全身感染者,创伤性溃疡均位于小腿。随机分为试验组20例,对照组20例。干预措施:试验组20例用无菌成纤维细胞生长因子生物蛋白海绵,对照组20例用无菌凡士林油纱布。更换敷料1次/d,至创面愈合止。全身和局部均不使用影响创面生长的药品。于换药1,2,3周对创面愈合情况进行评估(创面分泌物分为:无、少量、中量及多量;创面边缘反应分为:无、轻度、中度及重度)记录创面愈合后的色素沉着及瘢痕情况。主要观察指标:两组患者溃疡愈合时间、创面愈合过程及不良反应。结果:两组共40例患者均进入结果分析。①两组患者治疗后创面愈合情况:试验组3周内愈合率显著高于对照组[95%(19/20),55%(11/20),χ2=8.533,P<0.05]试验组创面分泌物及创周炎性反应明显轻于对照组创面V两组创面均未发现明显不良反应及瘢痕。结论:成纤维细胞生长因子生物蛋白海绵可促进创伤性溃疡面愈合,缩短愈合时间,且无瘢痕及明显不良反应,是一种安全、方便、无刺激的理想敷料。更多还原

【Abstract】 BACKGROUND: People have concerned with the effect of fibroblastgrowth factor biological protein sponge on the repairing effect of traumaticulcer.OBJECTIVE: To observe the repairingeffect offibroblast growth factor bi-ological protein sponge on the repairing effect of traumatic ulcer and itspossible adverse reactionDESIGN: Grouping comparison observation.SETTING: Staff Room of Physiology, Medical College of Jinan UniversityPARTICIPANTS: Totally 40 cases of traumatic ulcer accepted the treat-ment in the First Hospital of Jinan Univerity between March 2004 and May2005 were recruited. Patients with diabetes mellitus and infection on thewhole body were excluded. Traumatic ulcer lay in the shank. Patients wererandomly divided into experimental group and control group with 20 ineach group.INTERVENTIONS: In the experimental group (n=20), sterilized fibrob-last growth factor biological protein sponge was used and in the controlgroup (n=20), sterilized petrolatum gauze dressing was used on the wound.Change the gauze dressing once per day until the wound healed. Drugs,which affected wound growth, were not used on the whole body and at thelocal part. Wound healing status was evaluated 1, 2 and 3 weeks afterchanging the drugs (The secretion of a wound was divided into: nothing, alittle, middling, a great deal. frontier reaction of wound was divided into:nothing, slight, middling, severe.). Pigment deposition and scar was record-ed after wound healing.MAIN OUTCOME MEASURES: Healing time of ulcer, healing courseof the wound and adverse reaction of the patients in the two groupsRESULTS: Totally 40 patients of the two groups entered result analysis.Wound healing status after treatment of the patients in the two groups: Therate of wound healing in 3 weeks in the experimental group was signifi-cantly higher than that in the control group [95%(19/20), 55%(11/20),χ2=8.533,P < 0.05]. Wound secretion and peripheral inflammatory reactionof the wound in the experimental group was obviously milder than that ofthe control groupE there was no obvious adverse reaction and scar of thewound found in the two groups.CONCLUSION: FGF biological protein sponge can promote the healing oftraumatic ulcerE shorten the healing time without scar and adverse reaction.This dressing is convenient, safe, and non-irritative.更多还原