【摘要】 目的:通过临床观察衰老症状及指数,分析七宝美髯丹延缓衰老的机制。方法:共选入l50名老年健康者,为2001-01/2004-01哈尔滨医科大学附属第一医院体检中心的老年人,随机分为治疗组100例和对照组50例,分别给予口服七宝美髯丹及安慰剂胶囊,4粒/次,3次/d,连服2个月,服药前后对衰老症状及主要指标超氧化物歧化酶、血浆过氧化脂质、血浆睾酮、雌二醇及高密度脂蛋白胆固醇等进行评定及监测。结果:参选的150人全部完成数据采集,无脱落者。①衰老症状积分变化:治疗组衰老症状积分小于对照组(13.82±3.56,21.46±3.68,P<0.01)。②临床指标变化:治疗后治疗组治疗后超氧化物歧化酶活性大于对照组,过氧化脂质含量小于对照组犤(8215.31±1445.79),(4813.63±1024.87)nkat/g;(1.59±0.32),(3.09±1.06)mmol/L,P<0.01犦;治疗组睾酮大于对照组、雌二醇/睾酮值小于对照组犤(5764.0±1202.2),(4865.6±1432.8)ng/L;(0.0566±0.0176),(0.0698±0.0296),P<0.01犦;治疗组高密度脂蛋白胆固醇值大于对照组犤(2.18±0.09),(0.94±0.08)mmol/L,P<0.01犦。结论:七宝美髯丹可减少自由基对机体损害,能提高机体抗氧化活力,可调整脂质代谢紊乱,调节体内激素水平,起到补肾壮阳、抗老防衰、延年益寿的作用。更多还原

【Abstract】 AIM To analyze the mechanism of Qibao Meiran Dan in postponing aging through the clinical observation of aging symptoms and index. METHODS A total of 150 elderly healthy persons who were selected from the physical examination center of the First Affiliated Hospital of Harbin Medical University between January 2001 and January 2004 were randomly divided into treatment group n=100 and control group n=50. The subjects in the two groups were administered respectively with Qibao Meiran Dan and placebo capsules 4 pills for each time three times a day for 2 continuous months. Before and after the medication the aging symptoms and main indexes such as superoxide dismutase lipid peroxide testosterone estradiol and high density lipoprotein-cholesterol in plasma were assessed and monitored.RESULTS All the 150 subjects were involved in the analysis of results. ① Changes of the scores of aging symptoms The score of aging symptoms in the treatment group was lower than that in the control group 13.82±3.56 21.46±3.68 P < 0.01. ② Changes of the clinical indexes After treatment the activity of superoxide dismutase was higher and the content of lipid peroxide was lower in the treatment group than in the control group 8 215.31±1 445.79 4 813.63±1 024.87 nkat/g 1.59±0.32 3.09±1.06 mmol/L P < 0.01 The content of testosterone was higher and the ratio of estradiol to testosterone was lower in the treatment group than in the control group 5 764.0±1 202.2 4 865.6±1 432.8 ng/L 0.056 6±0.017 6 0.069 8±0.029 6 P < 0.01 The high density lipoprotein-cholesterol was higher in the treatment group than in the control group 2.18±0.09 0.94±0.08 mmol/L P < 0.01. CONCLUSION Qibao Meiran Dan can decrease the organic damage caused by free radicals improve the organic activity of anti-oxidation and regulate the disorder of lipoid metabolism and the level of body hormone. So it plays a role in tonifying kidney and supplementing yang postponing aging and prolonging the life span.更多还原