【摘要】 目的:应用中药加味联合甲钴胺治疗顽固性带状疱疹后遗神经痛,观察其止痛效果。方法:选择2003-10/2004-06西安交通大学第二医院皮肤科收治带状疱疹后遗神经痛患者160例,按随机对照原则将持续疼痛1个月以上的带状疱疹后遗神经痛患者分为甲钴胺治疗组50例、中药加味组55例及中药加味联合甲钴胺治疗组55例;分组治疗中采用视觉模拟评分法观察止痛时间和止痛效果。结果:按意向处理分析,160例均进入结果分析。经治疗3周后,中药加味联合甲钴胺治疗组患者疼痛治疗有效率90.9%,甲钴胺治疗组患者疼痛治疗有效率72%,中药加味组患者疼痛治疗有效率70.9%,中药加味联合甲钴胺治疗组在止痛效果上与甲钴胺治疗组和中药加味组相比较差异意义非常显著(χ2=7.551,9.123,P<0.01)。结论:中药加味联合甲钴胺两种药物治疗顽固性带状疱疹后遗神经痛可以减轻患者疼痛症状,比单独应用一种药物效果明显。更多还原

【Abstract】 AIM:To investigate the analgesic effect of Chinese medicine plus mecobalamin in the treatment of postherpetic neuralgia in patients with refractory herpes zoster.METHODS:Totally 160 patients with herpes zoster were selected from the Department of Dermatology,Second Hospital of Xi’an Jiaotong University between October 2003 and June 2004.In a randomized controlled trial,the 160 patients who had continuous pain beyond 1 month were randomly divided into three groups:mecobalamin group(n=50), Chinese medicine group(n=55) and Chinese medicine plus mecobalamin group(n=55). Visual analogue scale(VAS) was used to observe analgesic time and effect during treatment in each group.RESULTS:According to the intention management,all the 160 cases were included in the result analysis.After 3 week treatment,the effective rate of analgesia was 90.9% in Chinese medicine plus mecobalamin group,72% in mecobalamin group and 70.9% in Chinese medicine group;therefore,the analgesic effect in the Chinese medicine plus mecobalamin group was significantly different from that in the mecobalamin group and Chinese medicine group(χ 2=7.551,9.123,PCONCLUSION:Chinese medicine plus mecobalamin for postherpetic neuralgia in patients with refractory herpes zoster relieves pain more obviously than either Chinese medicine or mecobalamin does.更多还原