【摘要】 目的:许多学者对运动性疲劳机制提出了不少假说。文章总结了前人的工作,结合部分运动生理学和运动分子生物学知识对运动性疲劳的分子生物学机制进行分析。资料来源:应用计算机检索Medline1990-01/2004-12期间的相关文章,检索词exercise-inducedfatigue,molecularbiologicalmechanism,mito-chondriaDNA,nervousmediator,oxygenfreeradical,并限定文章语言种类为英文。同时计算机检索重庆维普全文数据库1995-01/2004-12的相关文章,限定文章语言种类为中文,检索词为“运动性疲劳,分子生物学机制,线粒体DNA,神经递质,氧自由基。资料选择:对资料进行初审,选取细胞内分子、细胞膜分子、细胞外分子和细胞内外广泛存在的运动性疲劳分子生物学机制的相关内容。资料提炼:共收集到34篇与运动性疲劳分子生物学机制有关的文章,其中有26篇被本文直接引用,其余文献虽未有直接引用,但对于全文的写作具有一定的参考价值。资料综合:从引起运动性疲劳的细胞内分子(如信号传导因子、基因、连接蛋白、酶等)、细胞膜分子(如受体、膜转运蛋白、酶等)、细胞外分子(如激素、神经递质、细胞因子、转运蛋白、酶、免疫球蛋白、补体分子等)和细胞内外广泛存在的分子(如葡萄糖、脂肪酸、氨基酸和水、无机元素、氧自由基等)的大量研究发更多还原

【Abstract】 OBJECTIVE: Many scholars have suggested some hypotheses on the mechanisms of e xercise induced fatigue. This paper summarizes the works that predecessors have done, and analyzes the molecular biological mechanisms of exercise induced fat igue in accordance with some part of knowledge on sports physiology and sports m olecular biology. DATA SOURCES: Relevant articles in English published between January 1990 and December 2004 were searched in Medline with computer by using the of " exercise induced fatigue,molecular biological mechanism, mitochondria DNA,nervo us mediator,oxygen free radical".Meanwhile, Chinese relevant articles published from January 1995 to December 2004 were searched in China National Knowledge Inf rastructure (CNKI) and Chongqing Weipu full text database, the keywords were " exercise induced fatigue, molecular biological mechanism,mitochondria DNA,nervo us mediator,oxygen free radical" manually or by computer. STUDY SELECTION: After primary search of the data, contents related to the mol ecular biological mechanisms of exercise induced fatigue of intracellular molec ules, molecules on the cell membranes, extracellular molecules and molecules tha t could be found at inner and outer cells were selected. DATA EXTRACTION:Totally 34 papers related to the molecular biological mechanis ms of exercise induced fatigue were collected,and 26 of them were directly adop ted in this paper,other not adopted ones played an important role as references. DATA SYNTHESIS: The great amount of studies about exercise induced fatigue ca used by intracellular molecules (signal transduction factor, gene, conjunction p rotein, enzyme,etc.),molecules on the cell membranes (receptor, membrane transpo rter, enzyme, etc.), extracellular molecules (hormone, neurotransmitter, cytokin e, transporter protein, enzyme, immunoglobulin, addiment, etc.) and molecules th at could be found at inner and outer cells (glucose, fatty acid, amino acid, wat er, inorganic substance, oxygen free radical, etc.) showed that it was clearer t hat the molecules which could be found at inner and outer cells (fatty acid, bra nched chain amino acid, oxygen free radical) played an important role in exercis e induced fatigue, but it was still at the primary phase. CONCLUSION: The deep cognition to the mechanisms of exercise induced fatigue in molecular and genic aspects is just on the primary stage, and the mechanism o f exercise induced fatigue about the molecules that could be found at inner and outer cells is deeper.The mechanisms of exercise induced fatigue are resulted from the cooperation of many factors.更多还原