【摘要】 目的:研究血清胆固醇含量与心血管疾病和恶性肿瘤死亡危险性的关系,探讨胆固醇的最佳范围。方法:随访了1992-01/1993-12在韩国医疗保险公司投保,年龄40岁及以上的共698796人,随访期为7年;利用COX分析计算不同胆固醇水平与全部死亡原因、心血管疾病以及恶性肿瘤的死亡相对危险性。结果:血清胆固醇含量与全部死亡原因、心血管疾病死亡危险性呈“U”型关系,当胆固醇低于4.0mmol/L以及高于6.0mmol/L时,死亡的危险性均升高。血清胆固醇与恶性肿瘤呈负相关关系,血清胆固醇越高,死于恶性肿瘤的危险性越低。结论:血清胆固醇过低时死于心血管疾病以及恶性肿瘤的危险性均较高,胆固醇含量较高时死于心血管疾病的危险性升高,胆固醇介于4.5～5.5mmol/L是一个较为理想的水平。更多还原

【Abstract】 AIM:To study the association of serum cholesterol level with the mortality risk of cardiovascular diseases and malignant tumor,and investigate the best range of cholesterol level. METHODS:Totally 698 796 people aged 40 and above,who were guaranteed in Korea Medical Insurance Company between 1992 and 1993,were followed up for 7 years.The adjusted relative risk of different cholesterol levels with mortalities of all causes,cardiovascular disease and malignant tumor was calculated and analyzed with Cox proportional hazards model. RESULTS:Serum cholesterol levels showed a U-shaped association with the adjusted relative risk of mortalities of all causes,cardiovascular disease and malignant tumor.The risk of mortality was all increased when the cholesterol level was lower than 4.0 mmol/L or higher than 6.0 mmol/L.Serum cholesterol level was negatively correlated with malignant tumor,the higher the serum cholesterol level,the lower the risk of malignant tumor. CONCLUSION:Lower serum cholesterol level increases the risk of mortalities of cardiovascular disease and malignant tumor.Higher serum cholesterol level increases the risk of cardiovascular disease mortality.The serum cholesterol level ranged 4.5 to 5.5 mmol/L is an ideal level.更多还原