【摘要】 目的:将自动提取正电子发射计算机断层成像(PET)影像中大脑功能区的方法应用于运动皮质的分析,从脑区的水平研究上肢运动对大脑皮质的影响。方法:研究于2004-02/06在上海华山医院进行,共对6例右利手男性健康志愿者分别采集静息和运动右侧上肢后的脑部FDG-PET;将图像与图谱空间归一化后,按照Talairach图谱所确定的功能区的3D坐标从图像中提取出Level3和Level5脑区;以运动状态作为试验组,静息状态作为对照组,进行自身前后对照研究。对脑区经参考区归一化后的平均密度比值做配对t检验(α<0.05)。结果:左侧中央前回(P<0.009)、左侧中央后回(P<0.025)、右侧中央后回(P<0.015)、左侧Brodmann1～4,6,8以及右侧Brodmann4等功能脑区在运动状态下,新陈代谢明显升高,但左侧更加明显。结论:分析结果符合神经学原理,自动提取脑功能区的方法在分析运动对大脑皮质影响上是有效的。更多还原

【Abstract】 AIM:To apply the method which can extract functional areas of the cerebral cortex in positron emission tomography(PET) image automatically on the analysis of motor cortex and study the effect of upper limb movement on cerebral cortex on the anatomic area level. METHODS:The experiment was done in Shanghai Huashan Hospital between February and June 2004.Totally 6 right handed healthy volunteers were scanned by FDG PET on their brain at rest and during the movement of their right upper limbs respectively.After the PET images were spatially normalized onto the Talairach Atlas space,all functional areas in the Level 3 and Level 5 of the atlas were extracted from the PET images.Volunteers at resting state were classified as the control group,while those who had limbs move as the test group,and the auto control experiment was taken in this study.After the grey mean of the functional areas normalized by reference area were measured,its values of the relative area were analyzed with paired t test(α< 0.05). RESULTS:In the left cerebrum, the metabolism level of the functional areas, such as precentral gyrus(P< 0.009),postcentral gyrus(P< 0.025),Brodmann 1-4,Brodmann 6,Brodmann 8,increased significantly at moving state of limbs.The metabolism level of postcentral gyrus(P< 0.015) and Brodmann 4 in the right cerebrum also increased.However, the amplitude in the left cerebrum was higher. CONCLUSION:The result of the analysis shows an excellent coherence with the principles of neurology;the method that extracts functional areas of the cerebral cortex is effective in analyzing the effect of movement on cerebral cortex.更多还原