【摘要】 目的探讨脑梗死患者血清C-应蛋白(C-reactive protein,CRP)水平与病情严重程度及反预后的量化关系。方法对病程为2周以内的90例脑梗死患者进行入院时和1周后血清C-应蛋白水反平测定。入院时C-应蛋白测定值为CRP11周后检测值为CRP2据入院时C-应蛋白测定值进行反,;根反分组。A组:CRP1≤2.00m g/L,B组:2.00m g/L<CR P1≤9.50m g/L,C组:CRP1>9.50m g/L。应用美国国立卫生研究院卒中量表(NIH SS)及Barthel指数(BI)记分法,对入院时90例患者(NIH SS1及BI1)和随访的58例患者(NIH SS2及BI2)进行神经功能缺损程度评分。结果入院时血清C-应蛋白水平与发病时反及治疗后3个月随访时的神经功能缺损严重程度呈显著相关(P≤0.001),且这种相关性存在量化关系:CRP1≤2.00m g/L时,N IH SS1中位数为5.00分,BI2中位数为100.00分;2.00m g/L<CRP1≤9.50m g/L,NIH SS1中位数为7.00分,BI2中位数为85.00分;CR P1>9.50m g/L时,N IH SS1中位数为13.00分,BI2中位数为47.50分。入院时血清C-应蛋白水平与相应的神经功能缺损程度及治疗后3个月恢复期水平反之间差异具有显著意义(P<0.05或P<0.001)。血清CRP2水平与入院时及治疗后3个月时的神经功能缺损程度间差异无显著性意义(P>0.05)。结论根据脑梗死患者发病后2周内的血清C-应蛋白水平反更多还原

【Abstract】 Objective To study the quantitative correlations of C-reactive protein (CRP) levels with severity and outcome in ischemic stroke. Methods The C-reactive protein (CRP) levels were determined at admission (CRP1) and 1 week after admission (CRP1) in 90 pateints with cerebral infarction within 2 weeks after symptom onset. According to the value of CRP1 the patients were divided into Group A CRP1 ≤ 2.00 mg/L; Group B 2.00 mg/L< CRP1≤ 9.50 mg/L and Group C CRP1> 9.50 mg/L. The deficiency intensity of neurofunction were evaluated at admission (NIHSS1 and BI1, n = 90) and following up 3 months after admission (NIHSS2 and BI2, n = 58). Results The severity of neurofunction deficiency was significantly and quantitatively correlated with the levels of CRP in patients at admission and 3 months after admission (P ≤ 0.001). The median value of NIHSS1 and BI2 were 5.00 and 100.00 when CRP1≤ 2.00 mg/L; 7.00 and 85.00 when 2.00 mg/L< CRP1≤ 9.50 mg/L; 13.00 and 47.50 when CRP > 9.50 mg/L respectively. But there was no significant difference in serum CRP2 levels between that at admission and 3 months after admission (P > 0.05). Conclusion The severity of illness and prognosis might be evaluated in patients with cerebral infarction according to their CRP levels within 2 weeks after onset.更多还原