【摘要】 设计并由天然樟脑合成了3个新的C2对称的同时具备双磺酰胺和羟基磺酰胺结构的手性羟基磺酰胺配体,并对其在二乙基锌对芳香醛的对映选择性加成中的催化性能进行了研究,其中一个催化对氯苯甲醛和二乙基锌的加成反应获得了84%化学产率和51%e.e.。更多还原

【Abstract】 Three novel chiral hydroxysulfonamides,which have C₂ axis and both disulfonamide and hydroxysulfonamide structures,are designed and synthesized from natural camphor,and their use as ligands in the titanium tetraisopropoxide-promoted enantioselective addition of diethylzinc to aromatic aldehydes is studied.One of the ligands shows a good asymmetric induction in the catalysis of the reaction of p-chlorobenzaldehyde to provide sec-alcohol with 84% of a yield and 51% e.e.更多还原