【摘要】 J蛋白(J-domainprotein)是一类分子中含有J结构域的蛋白质大家族,大部分J蛋白具有分子伴侣的功能。J蛋白作为热休克蛋白70(HSP70)的同伴蛋白与HSP70组成分子伴侣机器,参与蛋白质分子折叠、组装、转运以及信号转导等多种细胞过程。此外,J蛋白在植物对环境胁迫的反应及其他生理过程中起重要作用。更多还原

【Abstract】 The characteristic feature of J-domain protein is the presence of the J-domain, a conserved approximately 75 amino acid sequence that forms multiple α–helices. The invariant tripeptide, HPD, is both charac- teristic and absolutely essential for the biological function of J-domain protein. The G/F-rich sequence proximal to the J-domain functions as a flexible linker region. Four repeats of CxxCxGxG together comprise the zinc-finger-like domain. J-domain proteins can function as co-chaperones in conjunction with HSP70 or in a multi-protein chaper- one machine. J-domain protein and HSP70 cooperate in many cellular processes, including protein folding, translo- cation and signal transduction. The Arabidopsis thaliana genome includes a large and diverse family of J-domain proteins. The 94 A. thaliana J-domain proteins, which have been divided into 51 families, are located in nucleus; cytoplasm; mitochondria; plastid; membrane and peroxisome respectively in the cell. The A. thaliana J-domain proteins are involved in response to many environmental stresses and physiological processes.更多还原