【摘要】 目的建立HPLC法同时测定舒巴坦钠和头孢曲松含量,考察组合制剂中舒巴坦钠和头孢曲松配伍的稳定性。方法采用反相HPLC测定配伍后0～6h内舒巴坦钠和头孢曲松的含量,同时观察配伍液在3种输液中的外观、pH值。结果配伍液中舒巴坦钠和头孢曲松的含量6h内均在96%以上,配伍液外观澄明,pH值基本稳定。结论舒巴坦钠和头孢曲松配伍后6h内较稳定。更多还原

【Abstract】 Objective To develop a method for the determination of sulbactam sodium and ceftriaxone by HPLC, and to investigate the stability of compatibility of sulbactam sodium and ceftriaxone. Methods Reversed phase high-performance liquid chromatography method was used to determine the contents of sulbactam sodium and ceftriaxone in three infusions at various time periods within 6 h. The outward character of the solution was observed and the pH was determined. Results When sulbactam sodium and ceftriaxone were mixed in three infusions within 6 h, the contents of both drugs were higher than 96%, and no obvious changes were found in pH and the outward character. Conclusions Sulbactam sodium and ceftriaxone were shown to be compatible within 6h when mixed in three infusions.更多还原