【摘要】 目的探讨男性原发性高血压患者ACEI(苯那普利)治疗期间饮用白酒对降压疗效的影响。方法采用前瞻性队列研究方法,用多元线性回归和Logistic回归对资料进行统计分析。结果经过15天ACEI治疗,饮酒组收缩压和舒张压下降幅度明显低于非饮酒组,且和饮酒量呈负相关剂量反应关系。其中,每天饮酒大于50ml饮酒组的收缩压和舒张压下降幅度与非饮酒组相比,分别少下降5.26mmHg(0.70kPa)(P=0.0116)和3.32mmHg(0.44kPa)(P=0.0349)。Logistic回归分析发现,每天饮酒大于50ml饮酒组,其收缩压降压有效率为非饮酒组的45%(P=0.0493),舒张压降压有效率为非饮酒组的76%(P=0.4750),但未达到统计显著性差异。结论男性原发性高血压患者在ACEI治疗期间饮用白酒降低降压疗效。更多还原

【Abstract】 ObjectiveTo explore the influence of alcohol consumption during ACEI (Benazepril) therapy on effectiveness of antihypertensive in male patients with essential hypertension.Methods A prospective cohort study was made and multiple linear regression and multiple logistic regression models were applied to data analysis.Results After 15 days ACEI therapy, the decrease in systolic blood pressure (ΔSBP) and diastolic blood pressure (ΔDBP) in alcohol-drinking groups was clearly smaller than that of non-drinking group. An inverse dose-response relation between alcohol drinking and (ΔSBP) as well as (ΔDBP) was observed either.To the non-alcohol-drinking group, subjects with alcohol-drinking more than 50ml per day showed 5.26mmHg(0.70kPa) (P=0.0116) and 3.32mmHg(0.44kPa) (P=0.0349) decreased in NSBP and DDBP, respectively. Logistic regression analysis demonstrated that the alcohol-drinking group’s effect rate of antihypertensive were 45% lower (P=0.0493) in SBP drop and 76% lower (P=0.4750) in DBP drop respectively compared with non-and alcohol-drinking groups. Conclusion Alcohol drinking during ACEI therapy can lower the effectiveness of antihypertensive in male patients with essential hypertension.更多还原