【摘要】 目的　探讨早断乳对高脂膳食大鼠血糖、血脂和激素水平的影响。方法　雄性Wistar大鼠出生后17天按体重随机分为2组,一组17天早断乳,另一组2 4天断乳。基础饲料喂养4周后,从2组各随机抽取12只动物处死,以进行动态观察。各组剩余的大鼠再按体重随机分为2组,一组给予高脂饲料,一组继续基础饲料,喂养6周。实验结束后处死动物,计算脂 体比,测定血糖、血脂和激素水平。结果　早断乳大鼠体重、体脂含量增加显著高于正常断乳组(P <0 . 0 5 ) ;血糖、血脂、胰岛素、瘦素水平升高,高密度脂蛋白、游离T3水平降低(P <0 . 0 5 )。结论　早断乳大鼠摄入高脂膳食后发生肥胖的倾向更明显。更多还原

【Abstract】 Objective To observe the effects of early weaning on the blood glucose,blood lipid and hormone of rat fed a high fat diet. Methods Male Wistar rats were randomly divided into two groups after born 17 days according to body weight. One group was early weaned in the 17th day, the other was breastfed until the 24th day. After 4 weeks fed with basic diet, 12 rats were randomly selected from each group and were sacrificed. The other rats of each group were further randomly divided into 2 groups according to body weight. One group was fed a high fat diet, the other was fed the basic diet. The rats were sacrificed respectively at the end of the experiment. The blood glucose, serum lipids and hormones were measured. Results Compared with the normal weaning rats, the weight and fat pad of early weaning rats significantly increased and the level of blood glucose,serum lipids, insulin, leptin also increased significantly（P<0.05）,the level of HDL,FT₃ decreased（P<0.05）. Conclusion The tendency of obesity in early weaning rats were more obvious than normal weaning rats after fed a high fat diet.更多还原