【摘要】 目的观察2型糖尿病T2DM和糖耐量低减IGT患者血清C反应蛋白CRP的水平,探讨CRP在高血糖发生中的作用。方法所有受试者均经口服葡萄糖耐量试验OGTT,用乳胶增强速率免疫散射比浊法测定三组受试者血清CRP水平。结果正常对照NCI、GT和T2DM者血清CRP水平逐渐升高,分别为(1.31±0.47)mg/L、(2.43±0.40)mg/L和(3.95±0.88)mg/L,组间比较差异有统计学意义,以下同(P<0.01);CRP分别与体重指数BMI、腰围、收缩压、舒张压、空腹血糖FPG、OGTT2 h PG、HbA1c、胰岛素抵抗指数HOMA-IR、三酰甘油三酯TG和总胆固醇TC呈正相关。结论慢性低度炎症不仅在T2DM而且在IGT状态已经存在。更多还原

【Abstract】 Objective To observe the levels of C-reactive protein(CRP) in patients with type 2 diabetes mellitus(T2DM)and impaired glucose tolerance(IGT),and to study the rule of CRP in the development of hyperglycemia.Methods All subjects in the study underwent a 75 g oral glucose tolerance test(OGTT).Determination of serum CRP levels in normal controls(NC),IGT and T2DM patients was made by latex-enhanced immunonephelometric assay.Results The serum levels of CRP were 1.31±0.47mg/L in NC,2.43±0.40 mg/L in IGT patients,and 3.95±0.88 mg/L in T2DM patients.The serum levels of CRP were positively correlated with body mass index(BMI)(r=(0.275),P<0.05),waist circumference(r=0.354,P<0.01),systolic blood pressure(r=0.247,P<0.05),diastolic blood pressure(r=0.233,P<0.05),fasting plasma glucose(FPG r=0.513,P<0.01),OGTT 2 h PG(r=0.526,P<0.01),hemoglobin A1c(HbA1c r=0.483,P<0.01),homeostasis model assessment index of insulin resistance(HOMA-IR r=0.503,P<0.01),triglyceride(r=0.381,P<0.01),and total cholesterol(TC)(r=0.282,P<0.05).Conclusion Low-grade chronic inflammation exists not only in patients with T2DM but also in patients with IGT.更多还原