【摘要】 目的为探讨PGE1治疗慢性重型病毒性肝炎的机理和价值。方法本文观察了31例慢性重型病毒性肝炎患者PGE1治疗前后血浆内毒素、肿瘤坏死因子α(TNFα)、前列腺素E2(PGE2)水平及其他临床指标的变化。结果发现PGE1治疗有效患者血浆内毒素、TNFα、总胆红素(SB)水平下降,PGE2水平上升。结论应用PGE1治疗慢性重型病毒性肝炎可部分缓解病情和纠正重型肝炎的病理障碍,故可作为慢性重型病毒性肝炎综合治疗的一种有效药物。更多还原

【Abstract】 Objective On the purpose of further estimation of therapeutic effects on chronic severe viral hepatitis with PGE1.Methods we observed the plasma levels of endotoxin,TNF-α,PGE2 and changes of other clinical features before and after PGE1 treatment for 31 patients of chronic sevre viral hepatitis with PGE1. Results The decreased plasma levels of endotoxin,TNF-α,SB,ALT and the increased plasma level of PGE2 ,PTa were achieved after treatment. Conclusion Our studies suggested that PGE1 were effective for chronic severe viral hepatitis and corrected remarkedly pathological disturbance ,it can act as a effective drug in comprehensive treatment for chronic severe viral hepatitis.更多还原