【摘要】 目的观察氯诺昔康和曲马多用于乳腺癌手术后持续静脉镇痛的临床效果。方法60例ASAI~Ⅱ级择期行乳腺癌改良根治术患者,随机分为氯诺昔康组(L组,n=30)和曲马多组(T组,n=30),术毕完全清醒后静脉注射负荷剂量再连接镇痛泵装置,于用药后1、2、4、8、16、24、48h进行随访,记录各时点疼痛强度(PI)、疼痛强度差(PID)、疼痛缓解度(PAR)、疼痛缓解率和副作用。结果两组患者各时点的PI、PID、PAR差异无统计学意义,疼痛缓解总有效率相近,T组的恶心呕吐发生率高于L组,但差异无统计学意义。结论氯诺昔康用于乳腺癌改良根治术后持续静脉镇痛可提供与曲马多同样满意的镇痛效果。更多还原

【Abstract】 Objective To investigate the clinical efficacy of postoperative intravenous analgesia with lornoxicam or tramadol for patients with radical mastectomy. Methods Sixty patients ASA Ⅰ- Ⅱ, scheduled for radical mastectomy were randomly allocated into either lornoxicam (group L, n=30) or tramadoKgroup T, n=30) for continuous intravenous analgesia postoperatively. The patients administered intravenous analgesia continuously through an analgesic pump after loading dose. Pain intensity (PI), pain intensity difference(PID), pain relief (PAR) and possible adverse events were recorded at 1, 2, 4, 8, 16, 24, 48 h after the loading time. Results Statistical analysis revealed no significant difference in PI, PID, PAR and tatol analgasic efficacy between lomoxicam and tramadol groups. Lornoxicam caused fewer adverse effects such as nausea and vomiting than that tramadol. Conclusion Lornoxicam provides an identical efficacy as tramadol in the postoperative continuous intravenous analgesia in patients with radical mastectomy.更多还原