【摘要】 目的回顾分析硬膜外术后镇痛并发锥体外系反应5例的原因。方法单次硬膜外术后镇痛:氟哌利多2.5mg加吗啡1.5mg手术结束前15min硬膜外注射:连续硬膜外术后镇痛,先给负荷量氟哌利多2.5mg和吗啡1.5mg,继续给氟哌利多5-7.5mg和吗啡4-6mg,用生理盐水稀释至100ml,连续输注1ml/h。结果单次和连续硬膜外镇痛锥体外系反应发生率为0.07%(1/1523);连续硬膜外术后镇痛发生率为0.45%(4/895)。发生年龄16-34岁,发生时间在术后12～25h,氟哌利多用量为2.5～4.5mg。结论锥体外系反应与氟哌利多有关,即便小剂量用于硬膜外镇痛仍难以避免锥体外系反应,尤其是青少年。更多还原

【Abstract】 Objective Analyze the reasons of reaction of extrapyramidal system during postoperative epi-dural analgesia. Methods Single postoperative epidural analgesia with droperidol 2.5 mg and morphine 1.5 mg injected 15 min before the operation was over. Continuous postoperative epidural analgesia with loading dose, droperidol 2.5 mg and morphine 1.5 mg, then droperidol 5-7.5 mg and morphine 4-6 mg, diluted to 100 ml with 0.9% NaCl, was given using analgesia pump, 1ml/h. Results The incidence of the reaction of extrapyramidal system after single and continuous postoperative epidural analgesia was 0.07% (1/1 523 cases) and 0.45% (4/891 cases) respectively, aged from 16 to 34 years,occurring 12 h to 25 h after operation. The dose of droperidol injected was from 2.5 mg to 4.5 mg. Conclusion The reaction of extrapyramidal system is associated with droperidol, which is difficult to avoid it with low dose during epidural analgesia, especially in teenagers.更多还原