【摘要】 目的探讨川芎嗪并用ACEI对伴轻度高血压2型糖尿病患者尿α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)的影响。方法45例2型DM患者均伴轻度高血压,随机平均分成两组,治疗组(23例)服ACEI-苯那普利并用川芎嗪注射液,对照组(22例)服ACEI-苯那普利;分别与服药前及后2周、4周、8周用放射免疫法(RIA)测定患者尿α1-MG、β2-MG及尿白蛋白(Alb)。比较两组服药前后血压的变化。结果川芎嗪并用ACEI对伴轻度高血压2型糖尿病患者尿α1-MG、β2-MG排泄量的降低作用较单用ACEI类药的降低作用更明显(P<0.01),且对α1-MG的降低作用更显著(P<0.01)。其降低α1-MG、β2-MG及AER的作用与其降低血压的作用无明显相关关系(P>0.05)。结论ACEI类药非常适用于T2DM患者,尤其是α1-MG、β2-MG升高者,不论其血压正常或轻度升高。但合用川芎嗪其疗效更佳。这对阻止DN的发生及发展有着非常重要的临床意义。更多还原

【Abstract】 Objective: To study the effect of ligustrazine and low dosage angiotensin converting enzyme inhibitor（ACEI）-benazepril on α₁-microglobulin（α₁-MG） andβ₂-microglobulin（β₂-MG）out of urine of type 2 diabetes millitus（T₂DM） with non-hypertension or hypertension.Methods: Fortyfive cases with T₂DM associated with non-hypertension or hypertension were randomly divided into 2 groups.23 cases were in the treatment group and recevied ligustrazine and ACEI-benazepril.22 cases of only ACEI were in the control group.The treatment and control groups included 16 cases of high blood pressure,and the relationship of the variation of the blood pressure between the control and treatment groups were compared before and after the adminitration.Theα₁-MG,β₂-MG and albuminuria（Alb） were measured by the method of ratioimmunoassay（RIA） before and after the administration for 2 weeks,4 weeks and 8 weeks.Results: The ligustrazie and ACEI-benazepril reduced α₁-MG and β₂-MG significantly （P<0.01） in T₂DM with non-hypertension or hypertension,but the α₁-MG reduced more significantly（P<0.01） compared with the β₂-MG.The reduction of α₁-MG and β₂-MG was not significantly related（P>0.05） with the decrease of blood pressure.Coclusion: The ligustrazine and low dosage benazepril are fit for the treatment of the T₂DM patients with the higherα₁-MG,either with hypertension or non-hypertension,and has effect on the prevention of the development of DN.更多还原