【摘要】 目的　探讨肺耐药蛋白 (LRP) 和酸性谷胱甘肽- S- 转移酶 (GST-π) 在非小细胞肺癌 (NSCLC) 中的协同表达及其临床意义。方法　用SP免疫组化方法检测62例术前均未进行化疗的NSCLC组织中LRP、GST- π蛋白的表达情况。结果　在NSCLC中LRP、GST-.π蛋白表达的阳性率分别为75. 8% (47/62); 66. 1% (41/62)。LRP蛋白表达与肿瘤分化程度相关。GST -π蛋白表达与肿瘤组织类型、分化程度、有无淋巴结转移相关。LRP与 GST π阳性表达之间存在正相关关系。结论　LRP、GST -π在不同类型的NSCLC中均可表达, 但水平不同。更多还原

【Abstract】 Objective To investigate the synergic expression of lung resistance protein (LRP) and GST-π in non-small cell lung cancer (NSCLC) and its clinical significance.Methods S-P immunohistochemical method was used to detect the expression of LRP and GST-π in 62 cases of NSCLC who had not been treated by chemotherapy before surgery.Results In 62 cases of NSCLC,the positive rate of LRP and GST-π was 75.8 % (47/62) and 66.1 % (41/62) respectively.The expression of LRP was correlated significantly with differentiated degree of the tumor cells and the expression of GST-π was correlated significantly with histological type,lymph node metastasis,and differentiated degree of the tumor cells.There was a positive correlation between the expression of LRP and GST-π.Conclusion LRP and GST-π can be expressed but the expression level varies with the type in different types of NSCLC.更多还原