【摘要】 目的:比较呼吸衰竭患者的甲状腺激素水平及血气分析的变化,探讨氧分压和二氧化碳分压对甲状腺激素水平的影响。方法:选择呼吸科、ICU住院呼吸衰竭患者70例,健康对照组30例,于未吸氧时取桡动脉血行血气分析,清晨空腹安静状态下取静脉血查甲状腺功能,分析呼吸衰竭患者PaO2、PaCO2和甲状腺激素的相关关系。结果:急性、慢性呼吸衰竭组FT3、TT3、TT4均明显低于健康对照组(P<0.01),但急性呼衰组与慢性呼衰组无差别(P>0.05);急性呼衰组FT4明显低于健康对照组(P<0.05),而慢性呼衰组与健康对照组无差别;3组TSH无差别(P>0.05)。急性呼衰组患者的TT3与PaO2呈显著性正相关,FT3、FT4、TT4、TSH均与PaO2无显著性相关,急性组患者的甲状腺激素水平与PaCO2无显著性相关。慢性呼衰组患者FT3、FT4、TT3与PaO2呈显著性正相关;FT3、TT3与PaCO2呈显著性负相关;TT4、TSH与PaO2、PaCO2均无显著性相关。结论:研究表明,呼吸衰竭患者均可出现甲状腺激素水平减低,甲状腺激素的变化在一定程度上受PaO2降低、PaCO2升高的影响,血清T3、T4的测定有助于评估呼吸衰竭病人的病情。更多还原

【Abstract】 Objective To observe the thyroid function and blood gas analysis among the patients with acute and chronic respiratory failure. And to investigate the relationship between thyroid hormones and PaO2 PaCO2. Methods Retrospective study on the medical/intensive care unit in our hospital 70 patients were admitted in the study. Immediately the blood sample was taken for BGA without inhaled oxygen at admission and at 8 00Am on the subse-quent day blood samples were taken for measuring serum total (TT4) and free thyroxine (FT4) total (TT3) and free tri-iodothyroxine(FT3) thyrotropin (TSH)concentrations. The same tests were proceeded on 30 health subject. Results The value of FT3,TT3 TT4 in patients with respiratory failure were showed obviously lower than control group there were no difference between acute and chronic groups. In acute group FT4 was lower than control group but hadn’t difference between chronic and control groups. No differ among the three groups serum TSH existed. PaO2 did not differ in two groups PaCO2 were significantly more in chronic RF group than acute RF group. PaO2 in patient with acute and chronic RF had positive relation with TT3 PaCO2 in the patients with chronic RF had a negative relation with FT3 TT3(P<0.05). TT4 and TSH in the patients with HF had no relation to PaO2 and PaCO2 (P>0.05). Conclusion 1.In patients with RF SES take place 2.SES seems to related to the decrease of PaO2 and increase PaCO2 statistically significant positive relation between TT3 and PaO2 in patients negative correlation between FT3 TT3 and PaCO2 in chronic RF. The fact suggests that measuring thyroid hormones concentration is useful it can evaluate the state of illness in patients with RF.更多还原