【摘要】 目的通过动物实验的方法,分析不同MRI成像方法对显示肝组织缺血的敏感性。方法S-D大鼠随机分成A、B、C三组,A组做右侧肝动脉与门静脉分支双重结扎,B做右侧门静脉分支单独结扎,C为对照组。A、B组动物再分别分为三个亚组,分别于术后12、24、72h进行MRI检查。结果两种血流阻断法引起肝右叶形态及T1、T2及DWI信号发生了不同变化:A组肝右叶即发生凝固性坏死,体积大小无明显变化;T2WI及DWI上表现为明显高信号。B组术后24、72h后右叶体积变小,颜色变暗,左叶代偿性变大;T2WI上肝右叶为中等略低信号,T1WI呈略高信号,DWI上信号强度明显降低。结论大鼠肝动脉与门静脉均结扎与单独门静脉结扎后肝组织在T1WO、T2WI和DWI上表现不同,以后者更为敏感、准确。更多还原

【Abstract】 Objective To evaluate the sensitivities of different MR imagings in revealing hepatic ischemia.Methods S-D rats were divided radomly into A,B and C groups.Right hepatic artery and right portal vein were ligated in A group; right portal vein was ligated only in B group; and C was control group.A and B were divided into 3 subsections respectively.MRI was examined after 12、24 h and 72 h,respectively.Results Two different ligations resulted in different changes in both morphology of hepatic roght lobe and signals on T1WI,T2WI and DWI.In Group A, hepatic right lobes resulted in coagulation necrosis with no significant morphological change,but distinct hyperintensity on T2WI and DWI appeared.In Group B, after 24h and 72 hof ligations, right lobes were atrophied and darkled, the rest lobes became hypertrophied.On T1WI and T2WI, right lobes showed isointensity or slight hypointensity, but distinct hypointensity on DWI.Conclusion In Groups A and B, hepatic lobes show different signals on T2WI and DWI.DWI is more sensitive and exact than T2WI.更多还原